Senior Staff Scientist, HVTN/CoVPN Laboratory Research
Fred Hutchinson Cancer Research Center
Location: Seattle, Washington
Internal Number: 22822
Fred Hutchinson Cancer Center is an independent, nonprofit, unified adult cancer care and research center that is clinically integrated with UW Medicine, a world leader in clinical care, research and learning. The first National Cancer Institute-designated cancer center in the Pacific Northwest, Fred Hutch's global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy, and COVID-19 vaccines has confirmed our reputation as one of the world's leading cancer, infectious disease and biomedical research centers. Based in Seattle, Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy, and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures for the world's deadliest diseases and make life beyond cancer a reality.
At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.
The Fred Hutch offers a vibrant intellectual environment within a beautiful lakeside campus in Seattle's South Lake Union biotech hub. The Fred Hutch campus contains five major research buildings along with the Seattle Cancer Care Alliance and is in close proximity to major research partners, such as the University of Washington School of Medicine, Seattle Children's Research Institute and the Allen Institute for Immunology.
We have an exciting opportunity for a Senior Staff Scientist in the McElrath lab in the Vaccine and Infectious Disease Division of our Fred Hutchinson Cancer Center in Seattle, WA. The position is ideally suited for a scientist with research interests in human immune-based mechanisms of prevention of infectious diseases of global health importance.
This position is a supervisory role for a good clinical laboratory practices (GCLP) compliant laboratory primarily evaluating cellular innate and adaptive immune responses following infection or vaccination to HIV, as well as other pathogens such as SARS-CoV-2 and Mycobacteria tuberculosis. Responsibilities include directing complex studies, hiring, supervising and mentoring personnel, and maintaining an internationally recognized, GCLP-compliant laboratory. This individual will plan and direct the development, validation and execution of assays to examine vaccine immunity and support product advancement (such as in go/no-go decisions), as well as exploratory research projects to answer in-depth immunological questions related to these infectious diseases. A special focus will be innate and T cell immunology and biomarkers. They will collaborate with internal and external stakeholders, academic scientists, clinical trialists, funders and industry partners.
Reporting to the HVTN Laboratory Center (HVTN LC) PI/SVP of the Vaccine & Infectious Disease Division, develop, direct and execute studies of cellular responses induced by diverse vaccine modalities and infections (e.g. HIV, SARS-CoV-2, HPV, P. falciparum, and Mtb) under investigation with a focus on Endpoint analyses and assay development, including but not limited to:
Provide day-to-day scientific and organizational leadership for the laboratory (up to 15 reports)
Mentor and develop talent, provide performance feedback and training opportunities
Oversee development and execution of GCLP and R&D cellular immune assays including but not limited to multiparameter flow cytometry, antigen-specific T cell phenotyping, intracellular cytokine staining, single-cell sorting and sequencing, cell-mediated viral inhibition, omics analyses, and other assays as relevant
Lead the establishment of new technologies and assays in the lab
Prepare and review data packages for identification of biomarkers and support go/no-go decisions for clinical product advancement
Prepare and present data at internal and external meetings and conferences
Prepare and submit in a timely way scientific articles, grant applications and progress reports
Identify ways to improve quality and increase capacity and efficiency of the work, including process improvements, communication, equipment, staff management and number of staff
Interface with collaborating researchers:
Lead scientific projects that collaborate with the HVTN LC and related research programs, including but not limited to the CHAVDs, BMGF CAVD, HIPC, ID-CRC, and VIMC
Participate in both formal and informal sharing of data amongst collaborating researchers
Interact with statistical collaborators, conducting analyses
Participate as a member of the HVTN/CoVPN leadership:
Provide immunological expertise in development of new clinical vaccine trials
Develop and participate in HVTN processes to develop new clinical trial protocols
Coordinate and implement specimen collection and analyses within the HVTN
Business development activities and interactions with industry partners:
Draft and/or review budgets, scopes of work, and contracts, for collaborations with industry sponsors/collaborators, such as IAVI, J&J, Sanofi Pasteur, Moderna, etc.
Maintain communications with external and industry sponsors including establishing and participating in regular teleconferences and correspondence regarding study plans, data transfer plans and packages, and other deliverables
Oversee development and iteration of validation experiments, approach and documentation for submission of a drug master file (DMF), including interactions with consultants and regulatory agencies, such as FDA
Prepare data analysis, supporting documentation and development of patent applications in conjunction with the Business Development group at the Fred Hutch
The ideal candidate will have a M.D. or Ph.D. in Immunology, or a related field, with at least 5 years of postdoctoral research experience in vaccines and human immunology
Supervisory and leadership experience with direct reports, including hiring, performance evaluation, and coaching/mentoring.
Expertise in high-dimensional multiparameter flow cytometry analysis, B and T cell human immunology and multiplex cytokine assays
Experience in collaborative team science and project completion is preferred, with the ability to create and manage project schedules, including tasks, deliverables, milestones and schedules
Motivation and adaptability are essential, as is a keen interest in the vaccine field
Proficiency in the use of computer programs such as MS Office, Illustrator or other drawing program, Prism or other graphing program, JMP and or SAS statistical analysis program, and FlowJo or other
flow data analysis program
The ability to travel up to 10% of the time domestically and/or internationally to represent the laboratory at meetings and conferences, as required
Hours: must be flexible, able to work some nights and weekends
Special qualifications: willingness to work with biohazardous (e.g., HIV-1) materials
Preferred qualifications include exceptional organization, written and oral communication skills, ability to oversee multiple tasks with attention to detail, a motivated/enthusiastic work style, and the ability to work in a fast-paced environment with a broad range of internal and external constituents
Fred Hutch has a mandatory COVID-19 vaccine requirement, with exceptions only for approved medical or religious accommodations. As a condition of employment, newly hired employees must provide proof of vaccination or initiate the accommodations process before their first day of employment.
A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and antiracism in your career or that will be made through your work at Fred Hutch is requested of all finalists.
Our Commitment to Diversity
We are proud to be an Equal Employment Opportunity (EEO) and Vietnam Era Veterans Readjustment Assistance Act (VEVRAA) Employer. We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability (physical or mental), marital or veteran status, genetic information, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at firstname.lastname@example.org or by calling 206-667-4700.
At Fred Hutchinson Cancer Research Center, teams of world-renowned scientists and humanitarians work together to prevent, diagnose and treat cancer, HIV/AIDS and other diseases. Researchers are discovering new ways to detect cancers earlier, improve treatments, and learn how to prevent cancers from growing. Although Fred Hutchinson opened its doors in 1975, its history began about 20 years before that. In 1962 Fred Hutchinson envisioned a center devoted to studying cancer, a disease that took his brother’s life. Today Fred Hutchinson is contributing to the next waves of breakthrough treatments and prevention strategies. Fred Hutchinson collaborates with the Seattle Cancer Alliance, the National Cancer Institute, and the University of Washington.