Lab Director-Hutchinson Cancer Research Institute Uganda
Fred Hutchinson Cancer Research Center
Internal Number: 22896
Fred Hutchinson Cancer Center is an independent, nonprofit, unified adult cancer care and research center that is clinically integrated with UW Medicine, a world leader in clinical care, research and learning. The first National Cancer Institute-designated cancer center in the Pacific Northwest, Fred Hutch's global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy, and COVID-19 vaccines has confirmed our reputation as one of the world's leading cancer, infectious disease and biomedical research centers. Based in Seattle, Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy, and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures for the world's deadliest diseases and make life beyond cancer a reality.
At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.
The Uganda Cancer Institute/Hutchinson Center Cancer Alliance ("UCI/HCCA") is a collaborative undertaking that has established a state-of-the-art cancer treatment and research facility located in Kampala, Uganda. The activities carried out by the Fred Hutch in Uganda in support of this alliance are performed under the auspices of the Hutchinson Centre Research Institute of Uganda ("HCRI-Uganda" or "HCRI-Ug"). A primary objective of the collaboration between the Global Oncology Program at the Fred Hutch and the Uganda Cancer Institute is the development of innovative, low-cost cancer prevention and treatment strategies that are appropriate for low- and middle-income countries (LMICs). The UCI/HCCA also has a strong focus on ameliorating the high burden of infection-related cancers in LMICs. Clinicians and scientists at the UCI/HCCA work together to enhance patient access to care, diagnosis, and research-based treatment. In addition to the UCI/HCCA, the Hutchinson Center's Global Oncology Program supports research activities in other countries, which collectively carry out the mission of the Program to conduct high-quality research and capacity-building on an international scale.
This full-time position will be located in Kampala, Uganda, and Seattle, Washington, USA, and will report to the Program Head, Global Oncology. This position requires a laboratory research scientist who will assume leadership of, and provide oversight for, the Global Oncology Program's laboratory operations at the UCI - Fred Hutch Cancer Centre ("UCI - Fred Hutch"), a 25,000-square foot cancer research and treatment building on Mulago Hill in Kampala that opened in May 2015. The laboratory facilities of the UCI - Fred Hutch are primarily located on the third floor of the building, and include a Specimen Processing Lab, Molecular Diagnostics Lab, Histopathology and Immunohistochemistry Lab, and BSL2+ Lab. There is dedicated space on the third floor for a future Genomics Laboratory Core. The UCI - Fred Hutch Labs currently support a range of observational and translational research programs as well as interventional clinical trials focused on infection-related cancers that are common In Uganda, including Burkitt lymphoma, cervical cancer, and Kaposi sarcoma, as well as other tumor types such as breast cancer and non-Hodgkin lymphoma. Investigators at the UCI - Fred Hutch also collaborate with several different independent laboratories in Kampala, who provide laboratory services not currently offered by the UCI - Fred Hutch.
The HCRI-Uganda Lab Director will work with the Program Head, Global Oncology, to oversee the UCI- Fred Hutch laboratories and staff, organize projects and processes, oversee research activities and maintain a first-rate set of laboratories compliant with GCP/GCLP guidelines. S/he will work with Program leadership to evaluate the laboratory program needs and establish priorities. The HCRI-Uganda Lab Director will direct and supervise all day-to-day UCI - Fred Hutch laboratory activities, administer laboratory policies, and manage laboratory staff. The Lab Director will work with the Global Oncology Program Head to extend the capability of the UCI - Fred Hutch labs. Finally, it is anticipated that the Lab Director will engage in research and grant writing and contribute to ongoing research projects in the component UCI - Fred Hutch labs as time and other duties permit.
Laboratory Activities and Projects - Kampala, Uganda
Work with the Fred Hutch/UCI principal investigators and HCRI-Uganda research and clinical teams to prepare the UCI - Fred Hutch laboratories for current and future research studies and interventional clinical trials to be run at the site.
Oversee establishment of advanced capabilities in the Molecular Diagnostics Laboratory such as high-throughput sequencing and automated PCR systems.
Identify, prioritize, and coordinate establishment of new techniques and assays in the component laboratories and their validation.
Evaluate, analyze, and prepare data for reports, abstracts, and publications.
Provide leadership/mentorship for, and training of, staff, visiting researchers/post-doctoral fellows and collaborators within the component laboratories.
Support investigators and collaborators during the preparation of grant applications to ensure that laboratory operations are adequately considered and budgeted for.
Evaluate the growth needs of the UCI - Fred Hutch laboratory program and establish priorities and development plans for meeting those needs. Work with Global Oncology leadership to create comprehensive strategic plans for short-term, mid-term, and long-term research goals. Drive forward the UCI - Fred Hutch research agenda.
Participate in both formal and informal sharing of data amongst collaborating researchers and funding agencies.
Act as a bridge between Hutchinson Center investigators and administrators in the US and HCRI-Ug staff in Uganda for on-going research activities.
Receive visitors to the UCI - Fred Hutch laboratory and establish connections and networks for future projects, protocols, and grants.
Participate in grant and protocol writing, overseeing the Laboratory assay sections.
Support the GO leadership in the set-up of a control cohort.
Operations Management - Kampala, Uganda
Oversee laboratory staff in accordance with Fred Hutch and Ugandan employment laws and regulations. Responsibilities will include oversight of hiring and training, management of day-to-day performance, and development and monitoring of corrective action plans for deficient or unacceptable performance. Complete written annual performance appraisals for all UCI - Fred Hutch laboratory staff.
Manage HCRI-Uganda laboratory personnel folders and training.
Develop and administer laboratory policies and procedures as per GCP/GCLP requirements. Review the laboratory Quality Management Plan. Oversee development, review, implementation, and continuous updating of SOPs and process development.
Support staff in creating new standard operating procedures and manuals that satisfy protocol, IRB, grant/contract, collaborator, and Hutchinson Center specifications, as needed.
Prepare, submit, and manage annual UCI - Fred Hutch lab operating budgets with the assistance of Hutchinson Center Global Oncology administrative staff. Sign off on purchase requisition forms.
Review quarterly Monitoring & Evaluation reports.
Oversee the direction of workflow in the component labs, and the execution of tasks by laboratory and ancillary staff.
Chair monthly laboratory and QA/QC meetings. Perform appropriate GCLP training for staff.
Chair and attend regular UCI - Fred Hutch Laboratory as well as Institutional Biosafety Subcommittee meetings.
Oversee and review all Laboratory Service Agreements with vendor laboratories/institutions.
Obtain accreditation, as appropriate, in UCI - Fred Hutch component laboratories. Act as main contact person for auditors and review and sign off on final audit responses.
Create and maintain a lab culture to reinforce and promulgate the Fred Hutch's core values of scientific excellence, respect for individuals, openness, and innovation.
Laboratory Activities, Projects and Operations Management - Seattle, Washington, USA
Oversee all aspects of the Warren Laboratory and its Research Projects with guidance from the Principal Investigator.
Supervise Warren Lab staff alongside the Principal Investigator, which includes hiring, training, performance and merit reviews, handling of disciplinary action, terminations and layoffs.
Serve as a liaison between Research Scientists and Administration to support the Warren Laboratory, the Global Oncology Program and the Program in Immunology, Clinical Research Division, and the Center.
Carry out complex research responsibilities in support of Warren Lab, Global Oncology and Program in Immunology projects/studies.
Support the HCRI-Uganda laboratories developing and establishing scientific operations and capabilities in Uganda and abroad.
Maintain IRB, IACUC, MTA and other documentation for the Warren Laboratory in addition to high-level scientific research activities abroad for the Global Oncology Program.
Manage all Warren Lab expenditures with assistance from the Research Administrator(s) and Warren Laboratory research staff.
Provide support in management of HCRI-Uganda laboratory expenses in conjunction with the Program Head of Global Oncology.
Participate and contribute to research funding/grant applications, grant progress reports, manuscript and abstract submission deadlines.
Maintain and develop business partnerships with Program in Immunology outside vendors, ensuring appropriate cost principles and policies.
Train Warren Lab and Program in Immunology staff in Good Laboratory Practice (GLP).
Act as a radiation and environmental safety officer for the Warren Laboratory, ensuring compliance with all radiation, chemical, and biohazard safety standards - including those pertaining to the use of the Isotope lab and liquid nitrogen storage tanks.
Coordinate lab meetings for the Warren Lab internally and externally.
Coordinate Warren Laboratory long-range planning, major equipment acquisitions, and new initiatives in conjunction with the Research Scientists, in order to achieve discounts and lower costs.
Maintain ongoing communication with all lab research staff on Warren Lab operations and the Global Oncology Program, soliciting direction or assistance from the Principal Investigator as required.
Create and maintain a Laboratory culture to reinforce and promulgate the Center's core values of scientific excellence, respect for individuals, openness, and innovation.
Promote integration of, and collaboration between, all Fred Hutch Global Oncology campuses and research sites, including the Day Campus in Seattle, the HCRI-Uganda, the Hutchinson Center Research Institute - South Africa (HCRI-SA), and all other sites at which Fred Hutch Global Oncology research activities are ongoing.
Establish strong working relationships with key stakeholders, including Fred Hutch Global Oncology Program investigators, other Hutchinson Center investigators, collaborating investigators at other US and non-US institutions, and local laboratory management in Uganda.
Publicly represent the HCRI-Uganda laboratory program with external constituency groups, including community, government, and private organizations.
Manage laboratory-based research collaborations with outside institutions. Engage with outside institutions as time permits to foster and cultivate new scientific collaborations.
Engage with Facilities Management on-site as well as the Facilities Group at Fred Hutch for laboratory building operations.
Foster a close working relationship between the HCRI-Uganda laboratory and HCRI-Uganda clinic in preparation for upcoming clinical trials. Establish a relationship with the UCI clinic and doctors, e.g. by participating in the weekly Lymphoma Tumor Boards.
Establish a strong working relationship with the Program Head, Global Oncology, to provide coordinated guidance on laboratory operations and function. Provide mentorship in laboratory leadership, as well as laboratory management, to HCRI-Uganda laboratory staff.
Establish policies and procedures to enable systematic workflow and steady growth of all laboratories in function and volume.
Identify the need for training requirements of the HCRI-Ug laboratory staff.
Hold and chair regular journal club meetings and research trainings.
Introduce staff to, and train staff in, LIMS and assay-related software applications in the HCRI-Uganda laboratory.
Other duties as assigned.
The ideal candidate will have a M.S. degree, or B.S. degree plus Post-baccalaureate experience with a minimum of 10 years of experience in a research-based laboratory and international laboratory-based experience.
Intimate knowledge of, experience with, and expertise in CAP and/or GCP/GCLP-compliant processing, cryopreservation, recording, and analysis of biospecimens for correlative studies to clinical trials are required.
The ideal candidate must exhibit teamwork, and excellent communication, organizational, and managerial skills.
The ideal candidate will have extensive experience in laboratory and biomedical research operations in limited resource settings in LMICs.
Fred Hutch has a mandatory COVID-19 vaccine requirement, with exceptions only for approved medical or religious accommodations.As a condition of employment, newly hired employees must provide proof of vaccination or initiate the accommodations process before their first day of employment.
A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and antiracism in your career or that will be made through your work at Fred Hutch is requested of all finalists.
Our Commitment to Diversity
We are proud to be an Equal Employment Opportunity (EEO) and Vietnam Era Veterans Readjustment Assistance Act (VEVRAA) Employer. We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability (physical or mental), marital or veteran status, genetic information, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at firstname.lastname@example.org or by calling 206-667-4700.
At Fred Hutchinson Cancer Research Center, teams of world-renowned scientists and humanitarians work together to prevent, diagnose and treat cancer, HIV/AIDS and other diseases. Researchers are discovering new ways to detect cancers earlier, improve treatments, and learn how to prevent cancers from growing. Although Fred Hutchinson opened its doors in 1975, its history began about 20 years before that. In 1962 Fred Hutchinson envisioned a center devoted to studying cancer, a disease that took his brother’s life. Today Fred Hutchinson is contributing to the next waves of breakthrough treatments and prevention strategies. Fred Hutchinson collaborates with the Seattle Cancer Alliance, the National Cancer Institute, and the University of Washington.