HVTN Lab Supervisor

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutchs pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nations first cancer prevention research program, as well as the clinical coordinating center of the Womens Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

The HIV Vaccine Trials Network (HVTN) Laboratory Center in the Immunology & Vaccine Development Program of the Vaccine & Infectious Disease Division is dedicated to understanding human immune responses and mechanisms of vaccine-induced immune protection against HIV, SARS-CoV-2 and other infectious diseases, such as malaria, Ebola and tuberculosis.

This position will be with the HVTN Laboratory Center in the Immunology & Vaccine Development Program within the Vaccine & Infectious Disease Division at Fred Hutch. The position will involve a supervisory role overseeing detailed evaluation of the immune responses to candidate HIV and SARS-CoV-2 vaccines in clinical trials as well as investigations of immune responses to HIV and SARS-CoV-2 (COVID-19) infections. It will also involve a supervisory role for a good clinical laboratory practices (GCLP) laboratory performing primarily cellular immune function assays. This individual will lead the development of assays and design of experiments to examine vaccine immunity and with collection and analysis of data. They will assist with implementation of laboratory QC procedures and records, assist with validation of assays for the GCLP laboratory and train technical staff. The incumbent will work in conjunction with the HVTN Laboratory Center GCLP and R&D teams to perform this job. They will develop techniques and design experiments to examine vaccine induced immunity, with a special emphasis on early innate immune responses, and will assist with collection and analysis of data.

Reporting to the HVTN Laboratory Senior Staff Scientist, coordinate and carry out the projects of the HVTN Laboratory Center activities with a focus on Endpoint analysis and R&D including but not limited to:

• Lead immune assays, primarily focused on T cell responses: high-dimensional multiparameter flow cytometry, intracellular cytokine staining, viral inhibition assays, multiplexed cytokine detection assays (MSD/Luminex), and other assays as relevant.
• Supervise, mentor, and train a team of research technicians.
• Analysis of flow data and results.
• Collaborate and coordinate with statistical groups and internal and external stakeholders.
• Participation in both formal and informal sharing of data amongst collaborating researchers.
• Assist with external progress reports and grant applications.
• Preparation of scientific articles.
• Coordinate establishment of new techniques in the laboratory.
• Other duties and projects as assigned.

• Ph.D. in immunology or a related field required, and experience in vaccines, infectious diseases, or human immunology
• Experience with multiparameter flow cytometry and analysis is required
• Special qualifications: willingness to work with biohazardous (e.g., HIV-1) materials, required
• Excellent communication (oral and written) and problem-solving skills are required
• Duties will require working in a team-oriented research environment and in serving in a collaborative and supervisory capacity. A strong background in collaborative team leadership, positive communication and project completion is preferred, with the ability to create and manage project schedules, including tasks, deliverables, milestones and schedules.
• Motivation and adaptability are essential, as is a keen interest in the vaccine field
• Knowledge of human clinical trials and/or GCLP/GLP experience is desired
• Proficiency in the following computer programs is necessary: MS Office, Illustrator or other drawing program, Prism, JMP and/or SAS statistical analysis program, and FlowJo and/or other flow data analysis programs
• Hours: Must be flexible, able to work some nights and weekends

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

We are proud to be an Equal Employment Opportunity (EEO) and Vietnam Era Veterans Readjustment Assistance Act (VEVRAA) Employer. We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability (physical or mental), marital or veteran status, genetic information, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at hrops@fredhutch.org or by calling 206-667-4700.