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At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.
The Orozco Laboratory in the Clinical Research Division is recruiting an experienced technician to oversee and perform laboratory experiments with radiolabeled monoclonal antibodies, both in murine tumor models and in vitro. This lab is part of a larger research group of investigators conducting innovative and exciting translational research to improve the outcome in acute myeloid leukemia and other hematological malignancies.
Ongoing research in the Orozco Lab focuses on developing and improving antibody therapies for leukemia and lymphoma patients, with the goal of translating laboratory findings into the clinic. In the laboratory, we are working to increase the effectiveness of radioimmunotherapy by developing pre-targeted methods for more selectively delivering radiation to tumor sites. We are also developing therapies that combine radioimmunotherapy and hematopoietic stem cell transplantation (HCT), with the goal of decreasing toxicities while increasing anti-cancer efficacy. One innovative application of our work is to replace total body irradiation and high-dose chemotherapy with radioimmunotherapy in conditioning regimens for partially matched (haploidentical) allogeneic HCT, as a means to reduce toxicity and thereby make HCT a potentially curative option for more patients.
Inject murnie with antibodies, drugs, tumor and/or hematopoietic stem cells in the tail vein, flank, and/or in the peritoneal cavity
Perform biodistribution experiments of radiolabeled antibodies in murine implanted with human tumors. These experiments would require drawing blood from the retro-orbital venous plexus, euthanizing murine and dissecting out tumors and normal organs
Grow human and murine tumor cell lines in tissue culture
Radiolabel antibodies with radioisotopes including Iodine-125, Iodine-131, Yttrium-90, Astatine-211 and others
Perform in vitro evaluations of chemotherapeutic agents and / or irradiation with cell lines
Perform basic mathematical and statistical analyses and standard lab computations; e.g., solution computations, cell dilutions, and antibody doses
Operate a variety of imaging instruments (like iQID, alpha-cameras, confocal microscopy) and analytical instruments (such as gamma counters, dose calibrators, cryostat machines, flow cytometers, luminometer and spectrophotometers).
Keep detailed records of experiments conducted; organize data; prepare data for analysis and presentation via software packages like excel and prism
Prepare specifications and quality control maintenance for equipment and supplies needed in support of research. Inventory and order supplies.
Conduct literature reviews to assist in determining most suitable methods to be used in research
Identify methodological problems in research protocol and implement modifications to optimize experimental results
Prepare and present written or oral progress reports concerning studies including assembly, organization, and interpretation of data
Detection of DNA damage via flow cytometry and microscopy approaches
Perform other laboratory duties as assigned by supervisor
This position requires a Bachelors degree in a biological field, and at least two years of bench-research experience with most techniques mentioned in the responsibilities section are required.
Basic tissue culture experience and knowledge of sterile technique are required.
Research Technician II minimum qualifications - BA/BS or extensive laboratory experience (4+ years). Independent research experience outside of laboratory coursework is usually necessary.
Research Technician III minimum qualifications - senior level position requiring extensive experience in a laboratory. Generally, the incumbent will posess a Master's degree in a related scientific field.
To be successful in this position, the technician must have good communication skills, be organized, motivated, and meticulous with respect to performance of assays, data collection and analysis.
The technician must be comfortable handling murine to properly give disease and/or therapies and be willing to work with small amounts of radiation on a regular basis in a very carefully controlled and monitored setting.
A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.
Our Commitment to Diversity
We are proud to be an Equal Employment Opportunity (EEO) and Vietnam Era Veterans Readjustment Assistance Act (VEVRAA) Employer. We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability (physical or mental), marital or veteran status, genetic information, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at firstname.lastname@example.org or by calling 206-667-4700.
At Fred Hutchinson Cancer Research Center, teams of world-renowned scientists and humanitarians work together to prevent, diagnose and treat cancer, HIV/AIDS and other diseases. Researchers are discovering new ways to detect cancers earlier, improve treatments, and learn how to prevent cancers from growing. Although Fred Hutchinson opened its doors in 1975, its history began about 20 years before that. In 1962 Fred Hutchinson envisioned a center devoted to studying cancer, a disease that took his brother’s life. Today Fred Hutchinson is contributing to the next waves of breakthrough treatments and prevention strategies. Fred Hutchinson collaborates with the Seattle Cancer Alliance, the National Cancer Institute, and the University of Washington.