Post-Doctoral Research Fellow, Hatch Lab

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutchs pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nations first cancer prevention research program, as well as the clinical coordinating center of the Womens Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employeeswho bringdifferent and innovativeways of seeing the world and solving problems.Fred Hutch is in pursuit of becoming an antiracist organization.Weare committed to ensuring that all candidates hired share our commitment to diversity,antiracism, and inclusion.

A fully-funded post-doctoral research fellow position is available in the Hatch Lab in the Basic Sciences Division. We study the structure and dynamics of the mammalian nuclear envelope, and our primary interests are to understand why and how nuclear membranes rupture and repair, and how defects in nuclear membrane stability impact cancer development (Hatch et al., Cell, 2013; Maciejowski and Hatch, Ann Rev Cell Dev Biol, 2020; Young, Gunn, and Hatch, MBoC, 2020). The Hatch lab uses a variety of techniques to achieve these goals with a focus on microscopy and cell-based tool development.

The fellow will be responsible for developing, in discussion with Dr. Hatch, and executing a project related to the core interests of the lab with the goal of developing a new line of inquiry that the fellow could start their own research program with, if desired.

Current areas of interest are: identifying proteins that drive membrane repair and how membrane gap size influences repair pathway choice, determining why chromatin state regulates nuclear lamina organization and membrane stability in micronuclei, developing new tools to track and isolate micronucleated chromatin and cells, and designing new experimental models to investigate how chromosome missegregation into micronuclei impacts cell transformation and tumor progression. The development of collaborative projects with other labs at Fred Hutch or elsewhere is of substantial interest.

Strong candidates will have demonstrated excellent abilities to independently design and execute a project, identify and communicate with scientists outside their lab to learn new techniques or topics, and effectively communicate the significance of their research in both oral and written presentations.

• A PhD in biology is required.
• First authorship on a published manuscript, or one close to submission, is required.
• The ability to clearly and efficiently communicate data, both in writing and verbally, is required.
• The ability to work independently is required.
• Experience with microscopy and quantitative image analysis is strongly preferred.
• Experience with immunological labeling techniques, including western blotting, flow cytometry, and immunofluorescence, is preferred.

To apply to this position please provide the following:

• Cover letter summarizing previous work experience and research interests,
• CV
• Contact information for three professional references.

We are proud to be an Equal Employment Opportunity (EEO) and Vietnam Era Veterans Readjustment Assistance Act (VEVRAA) Employer. We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability (physical or mental), marital or veteran status, genetic information, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our HR Operations at HRops@fredhutch.org or by calling 206-667-4700.