Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer and other life-threatening diseases. Fred Hutchs pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer with minimal side effects. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nations first and largest cancer prevention research program, as well as the clinical coordinating center of the Womens Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employeeswho bringdifferent and innovativeways of seeing the world and solving problems.Fred Hutch is in pursuit of becoming an antiracist organization.Weare committed to ensuring that all candidates hired share our commitment to diversity,antiracism, and inclusion.
Two Post-Doctoral Research Fellow positions are immediately available with Dr. Anthony Rongvaux, Ph.D. at Fred Hutchinson Cancer Research Center. The Rongvaux Lab uses state of the art humanized murine models to studies innate immune responses specific to the human species. This research has applications in both cancer and infectious disease modalities, and ranges from fundamental research to the development of novel drugs and immunotherapies.
Innate immunity and cancer Most cancer deaths happen because the cancer has spread to distant sites throughout a patients bodya phenomenon called metastasis. Why does metastasis occur, and how can we stop it to save lives?
It has been known for over three decades that a high density of macrophages in the tumor microenvironment correlates with metastatic progression and poor patient survival. However, the mechanisms by which macrophages support cancer remain incompletely understood. Our lab has developed unique humanized murine models for immuno-oncology studies. With these models, we have identified physiologically relevant macrophage populations involved in tumor support. We are currently studying the fundamental biology of these macrophages, and developing new therapeutic agents to target them.
Innate immunity to HIV infection Over 35 million people are living with HIV worldwide. About 40% of them dont have access to antiretroviral therapies, resulting in over half a million deaths annually.
Acute HIV infection induces a rapid inflammatory response, characterized by the production of large amounts of cytokines. However, this immune response is ineffective at controlling the virus. As a consequence, the virus can establish chronic infection and, if not treated, progress to a lethal disease. Understanding why the natural immune response to HIV infection does not confer protection, could help us design more effective vaccine strategies.
Using state of the art humanized murine models, single-cell RNA sequencing and genome editing, the postdoctoral fellows will study the mechanisms by which the immune system detects, and responds to transformed or infected cells. Understanding how the immune response fails to restore homeostasis is a prerequisite to design novel therapeutic or vaccine strategies.
Applicants will have a recent PhD in Immunology, Immuno-oncology, Cellular & Molecular Biology or a closely related field
The ideal candidate will have a research background in immunology with robust skills in molecular and cellular biology, and animal studies. Desirable skills include bioinformatics analysis, scientific writing and presentations
Strong interest in immunological applications in cancer and/or HIV infection.
To be successful in this position, the post-doctoral research fellow must be highly motivated with a track record of productive research, exemplified by at least one first author publication(s) and presentations, and willing to work in a highly collaborative, fast paced, collaborative and dynamic environment. These positions are suited to someone who enjoys mastering new skills, multitasking and working in a multiple team environment
Our Commitment to Diversity
We are proud to be an Equal Employment Opportunity (EEO) and Vietnam Era Veterans Readjustment Assistance Act (VEVRAA) Employer. We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability (physical or mental), marital or veteran status, genetic information, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our HR Operations at HRops@fredhutch.org or by calling 206-667-4700.
At Fred Hutchinson Cancer Research Center, teams of world-renowned scientists and humanitarians work together to prevent, diagnose and treat cancer, HIV/AIDS and other diseases. Researchers are discovering new ways to detect cancers earlier, improve treatments, and learn how to prevent cancers from growing. Although Fred Hutchinson opened its doors in 1975, its history began about 20 years before that. In 1962 Fred Hutchinson envisioned a center devoted to studying cancer, a disease that took his brother’s life. Today Fred Hutchinson is contributing to the next waves of breakthrough treatments and prevention strategies. Fred Hutchinson collaborates with the Seattle Cancer Alliance, the National Cancer Institute, and the University of Washington.