Cures Start Here. Fred Hutchinson Cancer Research Center (Fred Hutch), home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, Fred Hutchs five scientific divisions collaborate to form a unique environment for conducting basic and applied science. The Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Childrens, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest. Careers Start Here.
The Walter Laboratory in the Clinical Research Division is recruiting an outstanding postdoctoral research fellow to work as part of a team investigating new treatments for patients with acute myeloid leukemia (AML) primarily focused on improving existing, and developing novel, antibody-based immunotherapies, and rendering them safer for clinical application. Current projects include preclinical drug development/testing (in part with academic and industry partners), studies on mechanisms of action and resistance of antibody-based therapeutics and identification of strategies to overcome these limitations, and development of approaches to protect normal tissues from the toxicities of AML-targeted therapies (e.g. via use of genome editing). We anticipate this position will commence July/August 2020.
The newly hired fellow will work under the direction of the Principal Investigator and senior laboratory personnel and will be involved in the following techniques/duties:
Generation of recombinant antibodies and other protein therapeutics via transient and permanent expression systems
Conduct of immunization strategies to raise new antibodies
Generation of engineered/gene-edited human leukemia cells
Tissue culture of mammalian cell lines and patient-derived primary human cells
Antibody drug conjugate (ADC) cytotoxicity, antibody-dependent cellular cytotoxicity, T-cell and NK-cell cytotoxicity assays
Flow cytometry-based immunophenotyping, FACS isolation of mammalian cells
Purification, cloning, and manipulation of RNA, cDNA and genomic DNA
PCR and RT-PCR, including quantitative assays using qPCR
Lentiviral vector modification, lentiviral particle preps and viral transduction
Protein gels, immunoprecipitation, western blotting, immunofluorescence microscopy
General laboratory duties and maintenance of laboratory equipment
A recent PhD in a relevant field of biology such as immunology, cell and molecular biology, genetics, biochemistry, pathology, bioinformatics, or genome sciences
Ability to drive an individual project but also be highly collaborative with academic and industrial partners
Ability to work independently and with scientific rigor
Interest in academic career and applying for independent funding support
To be successful in this position, the postdoctoral research fellow must be organized, clear and concise in their communication, enthusiastic, a team player, and have a desire to establish a career as a future independent investigator.Fellowship opportunities are available through several philanthropic and government organizations; fellow will have administrative support for the application process.
Applicants must include:
Cover letter discussing your interest in this position,research interests and career goals
Contact information for three references
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At Fred Hutchinson Cancer Research Center, teams of world-renowned scientists and humanitarians work together to prevent, diagnose and treat cancer, HIV/AIDS and other diseases. Researchers are discovering new ways to detect cancers earlier, improve treatments, and learn how to prevent cancers from growing. Although Fred Hutchinson opened its doors in 1975, its history began about 20 years before that. In 1962 Fred Hutchinson envisioned a center devoted to studying cancer, a disease that took his brother’s life. Today Fred Hutchinson is contributing to the next waves of breakthrough treatments and prevention strategies. Fred Hutchinson collaborates with the Seattle Cancer Alliance, the National Cancer Institute, and the University of Washington.