Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutchs pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nations first cancer prevention research program, as well as the clinical coordinating center of the Womens Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Brent lab is seeking a Research Technician IV. In this position, you will contribute to understanding how cell signaling systems carry information and the causes and consequences of non-genetic phenotypic variation in signal and response. Specifically, you will lead work on design and construction of "controllers", complex artificial systems allowing chemically tunable variation-suppressed expression of genes in mammalian cells induced by different small molecules.
You will also be involved in/ help alpha test our efforts to develop Augmented Reality (AR) methods to aid biological research. That work applies original engineering approaches and custom-built hardware/ software devices to increase the performance and add new capabilities to contemporary AR devices. Our approach has combined "analytical" approaches to computer vision and object sensing, as well as complementary application of trained deep neural networks (NNs) to provide the same functions and guidance. The work benefits from 25+ years of experience by PI and Current Protocols founders in providing procedural guidance.
Like the controller project, the explicit aim of this AR work is to assist experimentation. If these projects are successful, your work will have contributed to accelerating the pace of scientific discovery, and democratizing access to biomedical methods worldwide.
For this position, we are hoping to find an extraordinary and dedicated individual. The lab is a multidisciplinary environment and offers a number of intellectual growth paths by which scientists willing to engage can continue to develop scientifically. This position will support research activities that include but are not limited to:
Generation of variation-suppressed expression constructs to control genes in mammalian cells
Generation and testing of large numbers of intermediate constructs carrying out subfunctions, en route to assembly and testing of the best expression controllers
Facility with contemporary DNA assembly methods including in vitro assembly and relevant construction methodologies in Saccharomyces cerevisiae
Use of software to plan DNA constructions and ability to quickly use lab and other image cytometric software to quantify gene expression in single mammalian cells
Use of flow cytometry and flow cytometric methods
Updating of standard molecular cell biology/genetic techniques, including retroviral and lentiviral gene transduction, CRISPR, and next generation sequencing analysis, as methods change, based on input from other scientists and literature
Engagement with rapidly developing AR and ancillary technologies to aid research projects, willingness to participate in developmental work that will enable others to benefit from this new medium, and possible help with translation to AR representations
Aid conventional training, supervision, and evaluation of laboratory staff and students
Development and updating of laboratory procedures, draft of reports and manuscripts, and presentation of data at lab meetings and scientific conferences
Collaboration with PI for the submission of research grants and the submission of progress reports to identify funding and manage projects and research studies
A bachelor's degree or higher in Biochemistry, Genetics, Cell Biology or related areas
At least four years of experience in a related area, or equivalent combination of education/experience, and a strong background in molecular biology, DNA work, mammalian cell culture, and demonstrated facility with contemporary DNA assembly methods
Previous experience with rigorous genetics in a prokaryotic system, or in the model systems S. cerevisiae, C. elegans, or D. melanogaster
At least 8 years of relevant research experience with some combination of genetics, molecular biology, single cell assays, DNA/genomic based analytical methods, and cell culture
Please apply by submitting a CV or resume, a cover letter describing your past research experiences and future goals as well as contact information for three references.
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At Fred Hutchinson Cancer Research Center, teams of world-renowned scientists and humanitarians work together to prevent, diagnose and treat cancer, HIV/AIDS and other diseases. Researchers are discovering new ways to detect cancers earlier, improve treatments, and learn how to prevent cancers from growing. Although Fred Hutchinson opened its doors in 1975, its history began about 20 years before that. In 1962 Fred Hutchinson envisioned a center devoted to studying cancer, a disease that took his brother’s life. Today Fred Hutchinson is contributing to the next waves of breakthrough treatments and prevention strategies. Fred Hutchinson collaborates with the Seattle Cancer Alliance, the National Cancer Institute, and the University of Washington.