Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutchs pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nations first cancer prevention research program, as well as the clinical coordinating center of the Womens Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Stamatatos/Pancera lab, within the Vaccine and Infectious Disease Division, works towards the development of safe and effective vaccines against HIV-1 and malaria. Our major emphasis is the design of protein immunogens and understanding the immune response following vaccination or natural infection. The subgroup led by Dr. Pancera focuses on structural characterization of these immunogens and their immune responses. The laboratory utilizes a wide range of in vitro and in vivo systems and cutting-edge technologies and techniques. Experimental approaches include high-throughput crystallography, specialized immunological methodologies and assays, molecular and cellular biology techniques, bioinformatics, and computational approaches.
Our lab is seeking an outstanding Research Technician I-II to work on a project involving the characterization of the humoral immune response following vaccination against HIV, malaria or other pathogens using X-ray crystallography and cryoEM and the designs of novel immunogens.
Responsible for crystallization of the proteins/antibodies complexes and for solving and refining their structures
Conduct protein expression and purification experiments, including affinity purification, Ion exchange and FPLC, related to the production of antibodies against viral glycoproteins for structural biology
May involve use of Electron Microscopy, molecular modelling or structure-based mutagenesis and design
May involve use of Bio Layer interferometry, SPR and ELISA
Initiate and carry out scientific projects, under the supervision of Dr. Pancera
Develop and demonstrate a thorough understanding of the scientific literature relating to the research topics.
The ideal candidate must be a risk taker, show initiative, willingness to take up new skills and responsibilities, and be a team player. Excellent attention to details and the ability to work independently are essential to success in this position, as are good communication and organizational skills. The candidate must be self-motivated, able to multitask and to work within a very collaborative environment. Candidates with backgrounds in areas such as virology, protein biochemistry, vaccine development are strongly encouraged to apply.
BS with 1-2 years of experience or MS is required
Significant expertise in X-ray protein crystallography highly preferred
On-hands experience with diverse aspects of Molecular Biology
Knowledge of Cryo-EM
Experience in X-ray crystallography including up-to-date knowledge of relevant programs including CCP4, and Phenix packages, protein purification, protein characterization, and a strong publication history
Expertise with tissue culture and immunological assays
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At Fred Hutchinson Cancer Research Center, teams of world-renowned scientists and humanitarians work together to prevent, diagnose and treat cancer, HIV/AIDS and other diseases. Researchers are discovering new ways to detect cancers earlier, improve treatments, and learn how to prevent cancers from growing. Although Fred Hutchinson opened its doors in 1975, its history began about 20 years before that. In 1962 Fred Hutchinson envisioned a center devoted to studying cancer, a disease that took his brother’s life. Today Fred Hutchinson is contributing to the next waves of breakthrough treatments and prevention strategies. Fred Hutchinson collaborates with the Seattle Cancer Alliance, the National Cancer Institute, and the University of Washington.