Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch\u2019s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation\u2019s first cancer prevention research program, as well as the clinical coordinating center of the Women\u2019s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The research in the Bernstein lab has primarily focused on developmental aspects of normal and leukemic hematopoiesis with the specific goal of developing novel therapeutic modalities. In these efforts we have identified maturation linked cell surface antigens and have utilized this information for developing methods for targeted therapy of hematologic malignancies and for isolating and characterizing normal and malignant human hematopoietic stem cells. Current studies of normal hematopoiesis are aimed at determining the role of the Notch pathway to direct primitive hematopoietic precursors to commit to a particular maturational pathway or to self-renew. These efforts are currently being extended in studies of CAR T-cell self renewal and differentiation. Recent studies of leukemia focus on how cells in the marrow microenvironment protect the leukemic stem cells from therapy.
At Fred Hutchinson Cancer Research Center, teams of world-renowned scientists and humanitarians work together to prevent, diagnose and treat cancer, HIV/AIDS and other diseases. Researchers are discovering new ways to detect cancers earlier, improve treatments, and learn how to prevent cancers from growing. Although Fred Hutchinson opened its doors in 1975, its history began about 20 years before that. In 1962 Fred Hutchinson envisioned a center devoted to studying cancer, a disease that took his brother’s life. Today Fred Hutchinson is contributing to the next waves of breakthrough treatments and prevention strategies. Fred Hutchinson collaborates with the Seattle Cancer Alliance, the National Cancer Institute, and the University of Washington.