The Stamatatos lab, within the Vaccine and Infectious Disease Division, works towards the development of a safe and effective vaccine against HIV-1. Our major emphasis is the design of protein immunogens and understanding the immune response following vaccination or natural infection. The laboratory utilizes a wide range of in vitro and in vivo systems and cutting-edge technologies and techniques. Experimental approaches include high-throughput crystallography, specialized immunological methodologies and assays, molecular and cellular biology techniques, bioinformatics, and computational approaches. Our lab is seeking an outstanding Postdoctoral Fellow to work on a project involving the de novo design of recombinant protein immunogens derived from the HIV-1 envelope glycoprotein.Cures Start Here . Fred Hutchinson Cancer Research Center (Fred Hutch), home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, Fred Hutch's five scientific divisions collaborate to form a unique environment for conducting basic and applied science. The Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Children's, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest. Careers Start Here.Responsible for the utilization of computational methods for the de novo design of proteins and for the structural alternation of existing proteinsConduct protein expression and purification experiments, including affinity purification, Ion exchange and FPLCMay involve use of Bio Layer interferometry, SPR and ELISAInitiate and carry out scientific projects, under the supervision of Dr. StamatatosDevelop and demonstrate a thorough understanding of the scientific literature relating to the research topics.Conduct and publish research in appropriate journals.PhD in Structural Biology, Protein Chemistry, Biochemistry or a related field is required with significant expertise in the de novo design of proteins.Expertise ROSETTA-based computational modeling is a must. Candidates with backgrounds in areas such as virology, protein biochemistry, and vaccine development are encouraged to apply. Additional expertise with protein expression and purification is a plus.The candidate must be a 'risk taker', show initiative, willingness to take up new skills and responsibilities, and be a team player. Excellent attention to details and the ability to work independently are essential to success in this position, as are good communication and organizational skills. The candidate must be self-motivated, able to multitask and to work within a very collaborative environment. Salary will be commensurate with (appropriate) experience.
At Fred Hutchinson Cancer Research Center, teams of world-renowned scientists and humanitarians work together to prevent, diagnose and treat cancer, HIV/AIDS and other diseases. Researchers are discovering new ways to detect cancers earlier, improve treatments, and learn how to prevent cancers from growing. Although Fred Hutchinson opened its doors in 1975, its history began about 20 years before ...that. In 1962 Fred Hutchinson envisioned a center devoted to studying cancer, a disease that took his brother’s life. Today Fred Hutchinson is contributing to the next waves of breakthrough treatments and prevention strategies. Fred Hutchinson collaborates with the Seattle Cancer Alliance, the National Cancer Institute, and the University of Washington.